Publications
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Unravelling the distribution of holmium microspheres following transarterial radioembolisation
Transarterial radioembolisation is a treatment for liver cancer that delivers radioactive microspheres into the liver via a blood vessel. These microspheres spread unevenly: some areas in the liver receive high radiation dose, others very little. In...
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Quantifying hepatic arterial blood flow with 4D flow MRI: an in vivo feasibility and repeatability study
Anne van den Brekel, Marnix C Maas, Ilse M Spenkelink, Willem C M van Tilburg, Joey Roosen, Daniel Giese, Ning Jin, Jurgen J Fütterer, J Frank W Nijsen Objective: To investigate the feasibility and repeatability of four-dimensional (4D) flow MRI for...
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Dose heterogeneity in transarterial radioembolization after fractional administration of holmium microspheres: a study in perfused human tumor-bearing liver explants under MRI
Anne van den Brekel, Kirsten de Vries, Veerle A Lantinga, Tess J Snoeijink, Arja Gerritsen, Milou Boswinkel, Joey Roosen, Alexandra G Arranja, Marius C van den Heuvel, Cyril Moers, Jurgen J Fütterer, Koert P de Jong, Vincent E de Meijer, Simeon J S...
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The influence of hepatic arterial blood flow rate on holmium microsphere distribution: an MRI study in perfused porcine livers
Anne van den Brekel, Jan L van der Hoek, Jaap G M Greve, H Remco Liefers, Milou Boswinkel, Simon J S Ruiter, Joey Roosen, Erik Groot Jebbink, J Frank W Nijsen Background: Transarterial radioembolisation (TARE) is a treatment for liver malignancies,...
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Lung shunting and radiation pneumonitis after holmium-166 TARE: a case study
Meike W M van Wijk, Marcel J R Janssen, Mark J Arntz, Bram H J Geurts, Laura A Michon, Eric T T L Tjwa, Joey Roosen, J Frank W Nijsen Purpose: The assessment of the lung shunting fraction (LSF) in yttrium-90 (90Y) or holmium-166 (166Ho) transarterial...
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Microspheres in Motion: Investigating the parameters that influence radioembolization
This thesis investigates which parameters influence the distribution of holmium microspheres during transarterial radioembolization (TARE), a treatment for liver tumors. Experiments using 3D-printed models and porcine livers show that catheter...
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Spatial distribution of fractionally administered holmium microspheres in non-tumorous human liver tissue: how livers survive transarterial radioembolisation
A. van den Brekel, T.J. Snoeijnk, V.E. de Meijer, M. Boswinkel, K.P. de Jong, J. Roosen, A.G. Arranja, J.J. Fütterer, S.J.S. Ruiter, J.F.W. Nijsen Background: Relatively high mean absorbed doses to the non-tumorous liver tissue (NTLT) are generally...
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In Vitro Investigation of Microcatheter Behavior During Microsphere Injection in Transarterial Radioembolization
T.J. Snoeijnk, J.L. van der Hoek, H. Mirgolbabaee, T.G. Vlogman, J. Roosen, J.F.W. Nijsen, E. Groot Jebbink Purpose: To experimentally investigate the behavior of a clinically used microcatheter during transarterial radioembolization (TARE) microsphere...
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Development and validation of an innovative administration system to facilitate controlled holmium-166 microsphere administration during TARE
M.W.M. van Wijk, G. van Wolfswinkel, M.J. Arntz, M.J.R. Janssen, J. Roosen, J.F.W. Nijsen Background To develop and validate a novel administration device for holmium-166 transarterial radioembolisation (TARE) with the purpose of facilitating...
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Intraprocedural MRI-based dosimetry during transarterial radioembolization of liver tumours with holmium-166 microspheres (EMERITUS-1): a phase I trial towards adaptive, image-controlled treatment delivery
J. Roosen, L.E.L. Westlund Gotby, M.J. Arntz, J.J. Fütterer, M.J.R. Janssen, M.W. Konijnenberg, M.W.M. van Wijk, C.G. Overduin, J.F.W. Nijsen Purpose Transarterial radioembolization (TARE) is a treatment for liver tumours based on injection of...
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Accuracy of holmium-166 SPECT/CT quantification over a large range of activities
L.E.L. Westlund Gotby, D. Lobeek, J. Roosen, M. de Bakker, M.W. Konijnenberg, J.F.W. Nijsen Background: Quantitative imaging is a crucial step for dosimetry in radionuclide therapies. Traditionally, SPECT/CT imaging is quantified based on...
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Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution
T.J. Snoeijink, T.G. Vlogman, J. Roosen, E. Groot Jebbink, K. Jain, J.F.W. Nijsen Purpose Transarterial radioembolization (TARE) is an established treatment modality for patients with unresectable liver cancer. However, a better understanding of...
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MRI-guidance during transarterial radioembolization: towards a personalized treatment approach
Transarterial radioembolization (TARE), also called selective internal radiation therapy (SIRT), is a treatment modality for liver tumours during which radioactive microspheres are injected into (subbranches of) the hepatic artery through a catheter....
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Joey Roosen
Postdoc Joey Roosen studied Medicine at the Radboud University Nijmegen. In 2019 he started his PhD project at the Department of Medical Imaging of the Radboud University Medical Center Nijmegen. During his PhD, he worked towards an MRI-guided approach...
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Image guided holmium radioembolization
while the patient is in an MRI suite. The feasibility of performing TARE in an MRI suite has been published recently (Roosen et al. 2022). Image-guided TARE enables alteration of the administered dose and the catheter positions during the procedure,...